Assessing Heterogeneity of Treatment Response with Diffusion MRI Tractography in Children with Autism Spectrum Disorder
Abstract
Greater than 80% of children with autism spectrum disorder (ASD) experience sensory differences that make it difficult for them to fully participate in meaningful everyday activities. There is extensive variability, or heterogeneity, in the types of sensory problems experienced. For example, some children with ASD are sensitive to lights and sounds, causing them to avoid social situations or environments that have unpredictable sounds. Some children with ASD are sensitive to touch, such that the clothes they wear or the materials that touch their hands cause them discomfort and/or behavioral dysregulation. Still other children with ASD have difficulty processing sensory information that contributes to the complex development of fine and gross motor skills. This heterogeneity in sensory subtypes makes it difficult for families to find the right sensory-based interventions to help ameliorate the specific sensory problem. In this research study, we will develop methods to expand our understanding about how sensory interventions might change sensory brain structures, allowing us to better predict which sensory interventions might work best for whom. Through our use of non-invasive magnetic resonance imaging, we will better understand how to design innovative interventions tailored to address specific sensory subtypes, thereby improving the daily lives of children with ASD who experience sensory differences.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Dec 05, 2021
- Source ID
- W81XWH2110594
Entities
People
- Stefanie Bodison
Organizations
- United States Army
- University of Florida