Replication Defects in Kidney Cancer
Abstract
This research will enable better understanding of the etiology and genetic risk factors for kidney cancer by innovatively identifying events on chromosomes during DNA replication that have the potential to serve as diagnostic or prognostic predictors of sensitivity or resistance to distinct therapeutic approaches. This work will determine how behaviors of the DNA replication machinery are influenced by abnormal genetic backgrounds of kidney cancers. This research primarily addresses the FY21 Kidney Cancer Research Program Area Conduct basic biology research to better understand etiology and cancer progression, metastatic disease, refractory disease and therapeutic resistance, genetic and environmental risk factors and the prevention of kidney cancer. This work primarily addresses the kidney cancer disease subtypes Clear Cell, Papillary and unclassified Renal Cell Carcinomas. Ultimately, this research will facilitate developing innovative new ways for subtyping kidney cancers based on defined DNA replication defects and, in the long term, is anticipated to be predictive for prognosis or for determining which therapies are best for treating an individual s unique cancer. In the long term, findings will highlight new strategies for identifying therapeutic approaches that positively impact mission readiness and the health of military members, Veterans, and the public.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Dec 28, 2022
- Source ID
- W81XWH2210136
Entities
People
- Ann L Kirchmaier
Organizations
- Purdue University
- United States Army