Mouse Modeling of Parathyroid Carcinoma
Abstract
Parathyroid carcinoma is a rare but often fatal disease. Treatment options for patients whose parathyroid cancer recurs after surgery, or who are not able to undergo surgery, are limited. Drugs that slow tumor growth may not be entirely effective, as most patients with surgically- incurable parathyroid carcinoma die from complications of high levels of blood calcium, caused by parathyroid hormone secretion by the tumor. Addressing the Focus Area of Research Model, this research proposal aims to create a new model system that would mimic the clinical course of aggressive parathyroid carcinoma in order to develop and test new preventative and therapeutic measures. This will be accomplished by generating a genetically-engineered mouse model carrying several genetic mutations commonly found in parathyroid cancer. While such a model would have the greatest benefit to patients with surgically-incurable parathyroid cancer and those carrying genetic mutations that predispose them to parathyroid cancer, patients with benign parathyroid tumors and primary hyperparathyroidism, a common disorder, will likely also benefit.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Dec 28, 2022
- Source ID
- W81XWH2210546
Entities
People
- Jessica Costa
Organizations
- United States Army
- University of Connecticut Health Center