Enhancement of Cellular Energy Sensor for Resuscitation from Traumatic Brain Injury with Hemorrhage
Abstract
One of the major causes of death in the battlefield is traumatic brain injury (TBI), and this is worsened when the TBI is accompanied with severe hemorrhage; thus, one of the greatest opportunities to reduce mortality and morbidity in the battlefield scenario involves appropriate treatment. These therapies need to provide fluid resuscitation and rapid restoration of the inadequate oxygen supply to the brain and the rest of the body. This proposal will test a novel target treatment based on the idea that the cellular energetic pathway is a key factor to better resuscitate from TBI with hemorrhage. The main goal of the present study is to find new ways to treat TBI in the presence of hemorrhage. High molecular weight (MW) polymerized human Hb (PolyhHb) is a newly developed blood substitute with promising results because of its high oxygen carrier capacity and will be tested as a resuscitation solution in the present study. Moreover, metformin will be synergistically tested with PolyhHb to enhance cellular energetic metabolism, and by that improve oxygen distribution and cellular function. Taken together, both the adequate resuscitation fluid and enhanced cellular energetic metabolism could be the key to increase survival from TBI in the presence of severe hemorrhage.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Dec 28, 2022
- Source ID
- W81XWH2210809
Entities
People
- Pedro Cabrales
Organizations
- United States Army
- University of California, San Diego