At-Home Video Assessment Using the Duchenne Video Assessment (DVA) to Advance Drug Development in Duchenne Muscular Dystrophy (DMD)
Abstract
Duchenne Muscular Dystrophy (DMD) is an inherited genetic disorder that causes the weakening of muscles of boys. As DMD progresses, participation in physical activities declines with age, and activities of daily living become harder to do independently. Many of the tests used in clinical settings and research trials do not reflect the daily lives of individuals with DMD and have led to the failure of many clinical trials. Casimir has developed the Duchenne Video Assessment (DVA). This outcome measure allows caregivers to capture videos of individuals with DMD using a mobile application on their smartphone/tablet in their home environment, completing prescribed activities of daily life. The DVA’s sensitivity will enable it to detect subtle changes that may occur with treatment. The tasks and the scoring of the DVA allow physical therapists to pick up on compensatory strategies that boys with Duchenne adopt as their muscle function changes. Our focus is to collect videos from 150 individuals with DMD completing the DVA and completing North Star Ambulatory Assessment and Performance of Upper Limb assessments over 2 years. With the completion of this project, Casimir will demonstrate the effectiveness of the DVA at detecting change so it can be used as an outcome measure in clinical trials that can show the everyday impact of new therapies on patients’ lives more accurately.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Dec 28, 2022
- Source ID
- W81XWH2210949
Entities
People
- Kristina Davis
Organizations
- United States Army