Therapeutic Screening for Traumatic Optic Neuropathy
Abstract
Traumatic optic neuropathy (TON) is a common consequence of battlefield or civilian injury to the eye or head and results in blindness. No treatment is currently available, at least in part due to the lack of suitable animal models for evaluating drugs that could improve visual function after injury. We have therefore developed animal models of this injury, as well as diagnostic tests by which the extent of visual deficit can be measured. Together, these offer a powerful tool for evaluating potential treatments. In this study, we will evaluate four drugs that are intended to prevent breakdown of the retina and optic nerve tissues in the aftermath of injury. By slowing or stopping these biological processes, it may be possible to retain or regain visual function. The drugs we have selected are also approved by the U.S. Food and Drug Administration for other diseases and may be quickly used for treatment of TON.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Dec 28, 2022
- Source ID
- W81XWH2210989
Entities
People
- Matthew A. Reilly
Organizations
- Ohio State University
- United States Army