Understaning the Interaction of Peptides and Proteins with Abiotic Surfaces: Towards Water-Free Biologics
Abstract
Aim 1 Develop systematic understanding of abiotic/biotic interfaces. We aim to understand, how the structure and activity of proteins and peptides immobilized on abiotic surfaces depends upon a) the chemical and physical nature of the abiotic surface; b) the physicochemical properties of the protein or peptide; and c) the nature of the surrounding medium Ð water, air or other hydromimetic molecules. Aim 2 Develop design rules for Òwater-free biologicsÓ based on engineered abiotic/biotic interfaces. Using knowledge gained from studies in Aim 1, we aim to a) engineer peptides and proteins with enhanced ability to retain structure and function in the absence of bulk water, and b) develop abiotic surfaces displaying hydromimetic functionality that stabilizes the native structure and function of biological molecules in extremely low humidity or Òwater-freeÓ interfaces Ð i.e. a surface-air interface that lacks bulk water and in air that is not humidified.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jun 25, 2021
- Source ID
- W911NF1110251
Entities
People
- Zhan Chen
Organizations
- Army Contracting Command
- United States Army
- University of Michigan