Resilience to Infection: an open innovation challenge to the community
Abstract
The objective of this proposed research is to explore the landscape of infectious disease research to determine the most viable approach for identifying molecular and biology factors predictive of and associated with infectious disease resilience in order to enable a subsequent community based open challenge to identify the most informative prognostic biomarkers for incorporation into clinical trials. This pilot project is designed as a feasibility study to develop the scientific framework to maximally identify biological modulators that confer resistance to infectious disease upon pathogen exposure. The project will be broken into three phases: (1) project development and data curation, (2) preliminary analysis of existing data to shape the question, and (3) an open innovation challenge to crowd-source the identification of additional data modalities and best solutions. The final outcome of this challenge will be a well-supported, defined protocol for the study of resilience to infectious disease. Definitions of resilience to be considered, in collaboration with DARPA program officers and external domain experts, include: identification of healthy individuals with asymptomatic response to severe, rare disease; identification of individuals with severe infections that escape sepsis; individuals with severe sepsis that escape death; or individuals directly challenged with a common pathogen that seroconvert in an asymptomatic manner. Data sources will include public and nonpublic sources of clinical trial data, as well as research-based molecular data including metabolomics, transcriptional, and DNA sequencing data.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jan 12, 2017
- Source ID
- W911NF1510107
Entities
People
- Lara M. Mangravite
Organizations
- Army Contracting Command
- Office of the Secretary of Defense
- Sage Bionetworks