A Comparative Approach to Understanding the Physiological Effects and Processing of Hydrogen Sulfide
Abstract
The objective of this proposed research is to answer the following questions: 1) what are the consequences of hydrogen sulfide exposure for enegy metabolism and performance in susceptible and tolerant populations?, 2) what are the endogenous hydrogen sulfide concentrations in susceptible and tolerant populations?, and 3) how do susceptible and tolerant populations modulate gene expression patterns in response to disruptions in hydrogen sulfide homeostasis? The investigators will test the different populations to determine how they respond to disruptions of hydrogen sulfide homeostasis They will establish the range of physiologically relevant, endogenous concentrations of hydrogen sulfide in organisms with different exposures. They will determine whether hydrogen sulfide tolerant populations are able to maintain low endogenous hydrogen sulfide concentrations when exposed to exogenous sulfide, or whether they are able to mitigate deterimental effects of elevated internal concentrations. Finally, they will use next generation sequencing to quantify transcriptomic responses in order to elucidate the physiological responses of living organisms to disruptions in hydrogen sulfide homeostasis.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jan 12, 2017
- Source ID
- W911NF1510175
Entities
People
- Michael Tobler
Organizations
- Army Contracting Command
- Kansas State University
- United States Army