Optimal Dynamic Control of Multiple Quantum Systems for Multiplexed Bio-network Analysis and Optogenetics
Abstract
This project seeks to investigate control strategies for manipulating multiple quantum systems. The objective of this research is to develop multiplexed and scalable quantum control tools for controlling light-sensitive proteins within their quantum dynamical regime of motion. This will be accomplished by drawing on the vast resources of laser pulse shaping to open new objectives that cannot be met by traditional photochemistry. Experiments will be performed in a variety of different bio-environments including in vitro cell-free circuits, bacteria, and tissues. ln particular. there will be three interrelated experimental and theoretical efforts undertaken with the goal of multi-species bio-molecular control while achieving an understanding ng of the mechanisms driving their dynamics. The three specific objectives are: (1) Achieve multiplexed optimal dynamic discrimination of biomarkers, (2) achieve multiplexed operation of optogenetic switches, and (3) obtain a mechanistic analysis of photonic reagent induced biodynamics for objectives 1 and 2. This experimental research will take advantage of laser pulse shaping techniques to achieve high finesse control of complex molecules, especially light-sensitive biomolecules. Experiments will be undertaken with the goal of finding optimal laser fields that will have the ability to control the quantum dynamics of two or more different large bio-molecules simultaneously . The investigations will build on two existing laser setups at Princeton designed to address the objectives of this research. ln addition, a DURIP grant to support this research was funded for the PI in FY 2015, making significant additional spectroscopic resources available for this project.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jan 12, 2017
- Source ID
- W911NF1610014
Entities
People
- Herschel A. Rabitz
Organizations
- Army Contracting Command
- Princeton University
- United States Army