Exploring the regulatory cross talk between the mitochondrial genetic system and stressful physiological conditions in the battlefield
Abstract
The objective of the proposed research is to determine whether mitochondrial variants impact higher order mitochondrial DNA organization and whether this modulates transcriptional regulation in response to stress. The investigators will determine whether mitochondrial transcription patterns change in response to changing physiological conditions. They will determine whether mitochondrial variants associated with altered mitochondrial transcription pattterns alter higher order mitochondrial DNA organization. If they identify an effect of mitochondrial variants on transcription they will determine whether these variants influence the transcriptional response to changing physiological conditions. The will measure the effect of stressors on mitochondrial DNA gene expression in cells that different in their mtiochondrial DNA. They will determine the effect of mitochondrial-nuclear genotype combination on mitochondrial DNA gene expression and examien their response to a repetoire of stressors.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jan 12, 2017
- Source ID
- W911NF1610334
Entities
People
- Dan Mishmar
Organizations
- Army Contracting Command
- Ben-Gurion University of the Negev
- United States Army