Multi-Analyte Advanced BioMaterials as Implantable Chemical Sensors (Multi-Analyte BioMICS)
Abstract
Profusa has developed innovative, tissue-integrating, soft sensors that overcome biofouling and the foreign body response and serve as a platform for the detection of multiple analytes. BioMICS (Advanced BioMaterials as Implantable Chemical Sensors) are comprised of miniaturized, injectable sensors and a disposable wearable patch reader that, together, provide continuous monitoring of soldier health status to improve mission efficiency without compromising mobility or readiness. Long-lasting injectable sensors that provide continuous, multi-analyte data will enable monitoring of metabolic status, ion panels, blood gasses, and other key physiological biomarkers. ProfusaÕs Lumeeª oxygen sensors have been functioning in humans for up to 4.5 years to date. Researchers have found these novel tissue-integrating sensors to be useful indicators of local tissue ischemia (e.g. wound healing, critical limb ischemia, tissue flap, stroke, burn, skin graft, tumor, tourniquet, REBOA, tissue engineering), as well as a measure of systemic hypoxia (e.g. altitude, exercise physiology, hypovolemic shock, sleep apnea, COPD, respiratory distress). In this work, we will expand our in vivo sensing platform to simultaneously detect a variety of sensing moieties (e.g. oxygen, glucose, lactate, carbon dioxide, pH, potassium, sodium, chloride). In addition to the development of these assays, we will demonstrate multiplexing capabilities, which poses many non-trivial technical challenges that need to be resolved to capture the full potential of the platform for health monitoring. We believe that the multiplexed analysis of continuous streams of in vivo biochemical data will provide invaluable decision-making guidance and replace point-in-time chemistry panels. Furthermore, we will advance the reader hardware and software, improve algorithms and data analysis methods, and develop appropriate pre-clinical models for testing the sensors with the goal of eventually providing unprecedented insights into health physiology.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- May 06, 2019
- Source ID
- W911NF1610341
Entities
People
- Natalie Wisniewski
Organizations
- Army Contracting Command
- Office of the Secretary of Defense