STIR: Multi-Modal Brain Interface System for the Study of Neurovascular Coupling
Abstract
The objective of this proposal is to combine optical techniques (including fluorescence microscopy, optical coherence tomography, and optogenetic stimulation) to study the fundamental concept in neuroscience of how regional neural activity is tightly coupled to hemodynamic signals in the brain. Tasking to acheive the objective of this proposal will include recording hemodynamic brain signals by monitoring changes in the diameter of blood vessels and blood velocity profiles. Tool development will also include the incorporation of spectral-domain optical coherence tomography and Doppler coherence tomography with 2-photon microscopy in order to record neural and astrocytic activity simultaneously. This hybrid imaging platform will be developed with the capability to be further combined with electrophysiology recordings to allow for optogenetic stimulation. Together, this system will permit simultaneous measurement of optical signals generated by blood flow dynamics, neural/astrocyte activity and optogenetic stimulation.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Feb 06, 2017
- Source ID
- W911NF1610407
Entities
People
- Ramin Pashaie
Organizations
- Army Contracting Command
- United States Army
- University of Wisconsin–Milwaukee