Peptidomimetics as Chemical Probes of Protein-Protein Interactions
Abstract
The National Defense Authorization Act for Fiscal Year (FY) 2016 and the Department of Defense (DoD) Appropriations Act for 2016 allocated $28M to assist Historically Black Colleges and Universities and Minority-Serving Institutions (HBCU/MI). The program aims to (a) enhance research programs and capabilities in scientific and engineering disciplines critical to the national security functions of DoD; (b) enhance the capacity of HBCU/MI to participate in defense research programs and activities; and (c) increase the number of graduates, including underrepresented minorities, in fields of science, technology, engineering, and mathematics (STEM) that are important to the defense mission. The FY 2016 DoD HBCU/MI Research and Education Program Broad Agency Announcement (BAA) solicited proposals from single investigators at HBCUs and MIs for the acquisition equipment and instrumentation in scientific areas important to one or more the three defense research offices, namely: Army Research Office (ARO); Office of Naval Research (ONR); and the Air Force Office of Scientific Research (AFOSR). All equipment/instrument grant awards made under this program will have a 12-month performance period. This proposal from Principal Investigator, Dr. Alexandra Orchard, requests support for the acquisition of a system of equipment that will be utilized in the design and synthesis of peptidomimetics that will interact with proteins related to human health and disease. The equipment will enable analysis of organic reactions and small molecules, the synthesis and purification of organic molecules, the monitoring of biological reactions using a variety of different assays, and computational modeling/docking for small molecule-protein interactions. The primary goal of the proposed equipment acquisition is to expand research capabilities at the university for two purposes: to increase research throughput leading to new discoveries in small molecular probes for protein-protein interactions, and to include more students in exciting cutting edge research that will increase their motivation to pursue a STEM major and/or career.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jan 12, 2017
- Source ID
- W911NF1610424
Entities
People
- Alexandra Orchard
Organizations
- Army Contracting Command
- Office of the Secretary of Defense