Chemical Countermeasures for CRISPR-Cas9/Cpf1 enzymes
Abstract
The CRISPR (clustered regularly interspaced short palindromic repeat) system is a microbial adaptive immune system that has furnished transformative biomedical technologies for targeted genome and epigenome editing, sequence-specific DNA recognition, targeted gene expression or repression, and genome imaging. We propose to employ tools and principles from genome engineering, organic chemistry and chemical informatics, and structural and computational biology to develop precision control of CRISPR-technologies.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Apr 01, 2019
- Source ID
- W911NF1610586
Entities
People
- Amit Choudhry
Organizations
- Army Contracting Command
- United States Army