7.3.1 Precision Polymeric Materials: Enhanced Enzymatic Catalysis in Organic Solvents -- Taking Biology Out of the Cell and Into Chemical Synthesis
Abstract
The aims of this yearÕs efforts were (1) Modification of a model enzyme with polymerization initiators/ chain transfer agent with subsequent growth of polymers from the protein (2) Study the impacts of polymer molecular weight and composition on enzyme activity. I. The results of major significance: was the finding that polymers could be grafted from lipase using photo induced electron transfer reversible addition chain transfer polymerization. The influence of polymer molecular weight and composition on enzyme activity was clearly observed form multiple lipase isoforms. ii. Additionally, we were able to grow polymers from bovine serum albumin that were capable of complexing transition metals. The resultant hybrids were used to synthesize drug like molecules. This effort resulted in the first publication supported by my award.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Feb 14, 2019
- Source ID
- W911NF1710015
Entities
People
- Saadyah Averick
Organizations
- Allegheny-Singer Research Institute
- Army Contracting Command
- United States Army