Broadband scanning microwave microscopy of biological cells and subcellular structures
Abstract
We propose to develop broadband scanning microwave microscopy (SMM) for characterization of the structure and properties of biological samples at the cellular and subcellular levels in collaboration with the group of Dr. James Hwang of Lehigh University, Bethlehem, Pennsylvania. Dr. Hwang has pioneered the techniques for broadband electrical sensing of individual biological cells at the micron scale that is fast, compact and label-free. SMM will allow the extension of the technique to the nanoscale. Compared to other non-contacting techniques such optical, X-ray or electron microscopy, SMM is highly noninvasive because the energy of microwave photons is only on the order of 10 µe V, which is too weak to damage biological samples such as live human cells which have been intensives investigated by Dr. Hwang s group. Compared to other nanoscale techniques such as atomic force microscopy (AFM) and scanning tunneling microscopy (STM), SMM has a unique capacity to probe buried and optically opaque structures down to the micron depth, which is critical for subcellular probing noninvasively. To this aim, a broadband approach allowing spectroscopic measurements, such as the one being introduced and investigated by the Pl Prof Marco Farina, Dn-Universita Politecnica delle Marchc, is of paramount importance.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Sep 11, 2018
- Source ID
- W911NF1710090
Entities
People
- Marco Farina
Organizations
- Army Contracting Command
- Polytechnic University of the Marches
- United States Army