A modular approach to the production of systems for the automatic and semi-automatic synthesis of molecules in plastic-ware
Abstract
Chemical manufacturing is often done at large facilities for specific products requiring large capital investment, and key products are only made for a finite period. We will develop an approach to the manufacturing of pharmaceuticals in a stand-alone plastic reactionware device as well as other proof of concept small molecules. The devices will be designed and constructed using a chemical to computer automated design (ChemCAD) modular approach enabling the translation of traditional bench-scale synthesis into a portable digital code allowing the production of a sealed, 3D printed device that can facilitate the entire synthetic route internally via simple operations with little automation or expertise. We will build apon our preliminary work aiming for molecules like the ?-aminobutyric acid receptor agonist, (±)-baclofen, establishing the idea more broadly paving the way for the local manufacture of molecule outside of specialist facilities, transforming supply chains, response times, and enabling the digitization of active pharmaceutical ingredients (APIs) to allow them to be manufactured and be perpetually available from a simple digital blueprint.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 23, 2018
- Source ID
- W911NF1710316
Entities
People
- Leroy Cronin
Organizations
- Army Contracting Command
- Office of the Secretary of Defense
- University of Glasgow