Instrumentation Proposal-Fabrication of a CMOS Integrated Circuit with Inter-Pixel Communication Networks for Neuroscience Applications of CMOS Nanoelectrode Arrays
Abstract
The CMOS nanoelectrofe aarray (CNEA) is a new electrophysiology tool that combines an array of surface vertical nanoelectrofes with a CMOS integrated circuit (IC). The nanoelectrodes are capable of intracelluar coupling, while the CMOS CI containing an array of stmulators and recording amplifiers enables the operation of the large-scale nanoelectroad array. With a support by the Army Research Office (ARO) under on-going contract W911NF-15-1-0565, we have demonstrated CNEAÕs with over a thouseand recording/stimulation sites, or pixels, that can massively parallelice intracellular recording across an electrogenic cellular network. This unprecedented merger of parallel and intracellular interfacing will benefir many areas of neuroscience, such as functional connectome construction, cellular neuroprosthesis, and pharmaceutical screening. The goal of the present instrumentation proposal is to support and enhance the on-going ARO funded research by fabricating a new CMOS IC that will even futher the capability of the CNEA, adding to its demonstrated parallel, intracellular interfacing. The newly fabricated IC will introduce a critical new fearture, an on-chip inter-pixel digital communication and control network. This feature-in conjunction with the parallel, intracellular interfacing-will enable us to exploit the spike-timeing-fependent plasticity (STDP) to create or erase cellular signal paths in neuronal networks by enhancing or reducing the synaptic connection strengths along the cellular paths. This ecploitation of the synaptic plasticity at the network level wil allow us to train neutonal networks and engineer their functional structures. The COMS IC fabricated theough this instrumentation proposal will thus all for high-precision interrogation of STDP-based learning and memory at the network level. Writing and erasure ation potential propagation paths can create new network functions and reapir pathological connections. Theis appriach thus may suggest novel strategies forbrain-machine interface, implanted devices, and neuroprosthesis. Combination of the electrical training and chemical modulation will aslo bebefit pharmaceutical screening for neurologicl disorders.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 16, 2018
- Source ID
- W911NF1710425
Entities
People
- Donhee Ham
Organizations
- Army Contracting Command
- Harvard University
- United States Army