A Two-Photon Mesoscope to Image the Activity of Millions of Neurons in the Primate Brain
Abstract
We propose to purchase an instrument that is optimized to measure the activity of massive populations of millions of neurons in non-human primates. We will incorporate opticallyaccessible electrodes into a large-scale imaging platform. The discoveries resulting from the deployment of this advanced technology will transform our understanding of the primate brain. In particular, this instrument will directly impact several DoD projects to develop novel braincomputer interfaces. A currently-funded project to research novel electrical recording and stimulation approaches to treat mental health disorders like depression and anxiety will benefit from the ability to image the activity of millions of neurons in the prefrontal cortex when neurons in other brain regions are stimulated. A currently-funded project to develop advanced neural interface technology to treat blindness using a fully-integrated thinned-CMOS electrode array with as many as 800,000 channels will benefit from the ability to image the activity of neurons immediately underlying the electrode array either simultaneously or immediately before and after recording. A currently-funded project to enhance decision performance for detecting and discrimination multimodal stimuli on a virtual reality display will benefit from the ability to measure cognitive state from the activity of large-scale circuits controlling attentional performance during sensory processing. Pending projects to develop fully-implantable optical interface to stimulate and record from the brain will also benefit from the ability to obtain subcellular resolution from neurons expressing fluorescent indicators on interleaved imaging sessions. Research-related education in computational neuroscience will benefit from the opportunity to develop novel concepts and computational tools for the analysis and understanding of large-scale brain networks guiding behavior. More broadly, the proposed instrument will create entirely novel trajectories toward neural technologies that restore and augment human capabilities.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- May 07, 2018
- Source ID
- W911NF1710520
Entities
People
- Bijan Pesaran
Organizations
- Army Contracting Command
- New York University
- Office of the Secretary of Defense