Chemical Sciences, Polymer Chemistry: New Chemical Tools to Synthesize and Characterize Sequence-Defined Polymers
Abstract
The overarching goal of this application is to create polymeric structures by the linking of sequence-defined oligomers. In this manner, the polymers will contain units of a set-sequence, although the units can be interchangeable. After screening combinatorial libraries of the polymers for biological, materials, or chemical sensing applications, they will be clipped apart at defined positions to release the oligomers for sequencing. The most important aspect of the choice of backbone functional groups is the ability to sequence the oligomers in a manner analogous to the Edman-degradation of peptides. Therefore, this application spans the gamut of novel synthesis; establishing new paradigms for linking and clipping for sequencing. The focus our efforts in this area will be on the synthesis and sequencing methodologies, while any screening of combinatorial libraries would be for future years.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 18, 2018
- Source ID
- W911NF1710522
Entities
People
- Eric Anslyn
Organizations
- Army Contracting Command
- United States Army
- University of Texas at Austin