Pathways Toward Improved Wound Healing for the Care of Wounded Warriors
Abstract
Innovative approaches are proposed to understand molecular and physiological underpinnings that have potential to translate to optimized protection of soldiers regarding wound microbiomes and the healing of craniomaxillofacial injuries. These approaches aim to identify and characterize gene function and regulation, molecular pathways, and gene expression patterns in wounds and wound pathogens. The proposed research continues our ongoing studies on the molecular basis of wound healing, including host and pathogen responses during wound infections. The scientific objectives are to: 1. Identify microbiome properties associated with wound healing. 2. Identify microbiome changes associated with biofilm-disrupting treatments. 3. Acquire wound images and apply algorithms for understanding features that may be associated with the subsequent healing of surgical site infected (SSI) dehisced wounds. 4. Analyze gene expression and pathways associated with the application of agents that modulate healing processes to understand potential ways to limit fibrosis and promote regenerative healing. These studies are significant because they develop knowledge that may ultimately transition to solutions for stabilizing and improving wound healing to retain functional capabilities and aesthetics after severe craniomaxillofacial injury.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Feb 14, 2019
- Source ID
- W911NF1810132
Entities
People
- Peter D Arpa
Organizations
- Army Contracting Command
- Geneva Foundation
- United States Army