Design of Protein Biomaterials Through Tailored Shape and Packing Strategies of Patchy Particles
Abstract
Building on our successes in using charge engineering of protein surfaces to created self?-assembled, protein building blocks that potentially can be used for the hierarchical construction of new biomaterials, we propose to now (i) expand our knowledge of the hierarchical assembly process with fluorescent proteins as substrates, (ii) apply this knowledge to new protein scaffolds, and ultimately (iii) use the engineered protein assemblies in 3D and ink jet printing and for the construction of functional silicate and metallated biomaterials. The experimental work carried out by the Ellington lab will be closely mirrored by molecular simulation studies carried out by the Glotzer group, which will provide guidance on experimental design and result in a generalized strategy for adapting any protein to becoming a building block for charge?-based assembly.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Aug 06, 2019
- Source ID
- W911NF1810169
Entities
People
- Andrew D Ellington
Organizations
- Army Contracting Command
- United States Army
- University of Texas at Austin