Increase of visual sensitivity by integration of multi-sensory information
Abstract
Sensory integration is an innate biological process that refers to the combination and/or interpretation of different types of sensory input in the brain. Defects in sensory integration may lead to serious neurological malfunctions, such as difficulties in position (proprioception), movement (vestibular system), or response to classic sensory stimulation (e.g., vision, olfaction, taste). The objective of the proposed research is to elucidate the mechanisms and possible roles of cross-modal sensory integration in modulation of visual system functions. The proposed research will be conducted in zebrafish and computer models. In Aim-1, we will identify retinal signaling pathways that mediate centrifugal input using the zebrafish models. In Aim-2, we will determine the role of melatonin from the pineal gland on the olfacto-retinal centrifugal visual pathway. This set of research will also be conducted using the zebrafish models. Based on the results obtained from laboratory animal studies, in Aim-3 we will create computational models that simulate the process of sensory information integration and predict the consequence of multi-sensory integration in higher-order brain functions. The significance of the proposed research is three-fold. 1) To elucidate the mechanisms underlying the integration of multi-sensory information in vertebrate species. The results will be highly applicable in humans, and the findings from this study will pave the way for future translational research. 2) To identify the role of endocrine hormones on visual pathways. The results will advance the knowledge of hormonal control of centrifugal visual modulation in human vision. 3) To develop computational models for multi-sensory information integration. These models will be useful for predicting complex visual behaviors in response to multi-sensory stimulation and create a unique capability for information fusion in artificial processing systems. In the long term, this research will have a direct impact for the accomplishment of the ArmyÕs mission. The results from this research will provide insights for the development of new strategies for visual enhancement for our soldiers, i.e., those that conduct tasks under unusual environmental conditions.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Feb 14, 2019
- Source ID
- W911NF1810292
Entities
People
- Lei Li
Organizations
- Army Contracting Command
- United States Army
- University of Notre Dame