Instrumentation for the Analysis and Design of Tunable, Stimuli-Responsive Biocatalytic Systems
Abstract
This proposal requests an automated isothermal titration colorimeter (ITC) to carry out detailed thermodynamic studies of biocatalytic networks (i.e., systems of enzymes that work together to catalyze the multi-step reactions that constitute cellular life). The ITC, in brief, enables precise measurements of the heat absorbed or released when two or more biomolecules associate; it will support research on (i) the mechanisms by which enzymes work together to perform complex operations (e.g., the iterative elongation of polymeric products or the rapid integration of chemical signals) and (ii) the construction of stimuli-responsive biochemical systems. These studies will answer broadly interesting questions relevant to information processing, low-power complexity, and biomolecular compatibility in living systems, and they will yield new approaches for building dynamically adjustable biochemical systems and adaptive materials.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 20, 2019
- Source ID
- W911NF1910135
Entities
People
- Jerome M Fox
Organizations
- Army Contracting Command
- United States Army
- University of Colorado Boulder