Correlation Interferometry and Time-resolved Spectroscopy to Elucidate the Origins of Radiation Brightening in Viromimetic Particles
Abstract
With support from the Army Research Oce (award W911NF-17-1-0329), we have discov- ered a uorescent, biologically-enabled viromimetic nanoparticle, which supports multiple, coupled emitters and exhibits bright collective emission at room temperature and at emitter densities that would normally completely quench emission. This is a unique system, with an intriguing behavior, which requires further basic study. The proposal deals with expanding our experimental capabilities to explore the conditions responsible for the newly discovered collective optical phenomenon, and develop an understanding of its physical origins and of ways of controlling it. The virus template has a major role; the e ect is not observed if we replace the virus template by a glass nanosphere or if we modulate the interaction between virus and chro- mophores to induce static or dynamic disorder. The mechanism behind the role of the virus template in the onset of collective behavior appears to be di erent from other previous instances of cooperative relaxation. To understand it, speci c instrumentation is needed. We propose to construct a comprehensive spectroscopic analysis system, including photon statistics with a Hanbury Brown and Twiss interferometer, single-particle uorescence life- time with a 25 ps resolution spectrometer, and transient absorption spectroscopy through the upgrade and inclusion of a set-up available in the lab. In addition, we will t the setup with an optical levitation chamber, which will made possible spectroscopic investigations of single particles free of substrate and solvent interference. Being able to pursue mechanistic studies of the origins of collective radiance in viromimetic particles could lead to results that will impact several cutting-edge technologies relevant to defense. For instance, the new technology could enable novel optical-neural interfaces, through selective, deep-tissue neuromodulation with high-spatial (subcellular) resolution of light-sensitive target neurons. Other technologies that could potentially bene t from col- lectively radiant viromimetic particles include quantum optical sensors, laser-guided micro surgery, and localized photocatalytic stimulation of metabolic processes.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jul 09, 2020
- Source ID
- W911NF2010071
Entities
People
- Bogdan Dragnea
Organizations
- Army Contracting Command
- Indiana University
- United States Army