Listening to the Bioelectronic Signature of Cells
Abstract
The objective of this research is to evaluate bioelectric effects at a cellular membrane and its corresponding vibrational signature, and study its evolution as a function of input vibrational stimuli to develop a new conjoined biology-circuitry paradigm with broad applications in Defense technologies. Our research will develop, apply and demonstrate a platform to read out these periodic response of bioelectric fields, process them using ML methods, and allow us to challenge the century-old paradigm to focus largely on chemistry to affect living processes, by exploiting instead the innate temporal gradients in field to detect cellular mechanisms/behavior, and to control the behavior of living organisms. The potential of this approach is vast, from basic biology to new interfaces between life and computers, novel AI methods, and enables a very exciting direction in neuromorphic computing, biomateriomic interfaces, which provide a seamless interface between computing hardware, software, and the algorithms of life. The deliverables include: 1. A method to process and analyze experimentally measured vibrational data (signal processing, spectral analysis); 2. Development of a ML classifier and relation to cellÕs living mechanisms under varied conditions (temperature, pH variations, voltage drivers); and 3. Development of a generative ML method to synthesize signals in distinct categories (see 2) to assess whether application of external signals can induce certain directed physiological effects.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jun 25, 2021
- Source ID
- W911NF2110178
Entities
People
- Markus J. Buehler
Organizations
- Army Contracting Command
- Massachusetts Institute of Technology
- United States Army