Understanding the Mechanism of Microwave Neuron Inhibition
Abstract
Electromagnetic wave, such as radio-frequency wave, has been used to modulate various biological systems for research, diagnosis and treatments. Microwave (MW) at GHz frequency has a wavelength of a few centimeters, enabling deep tissue penetration. It can be wirelessly delivered, which was already widely utilized in near-field communications. Therefore, MW promises a new biotronics for wireless non-invasive bio-modulation. MW-mediated inhibition of neuronal activity was reported as early as 1975, where a non-thermal mechanism based on perturbation of ion current inside an axon was proposed. Yet, the cellular and molecular mechanism of microwave neuron modulation has not been investigated and remains unknown. Understanding the mechanism of MW modulation offers a great opportunity for unique control of neural activities. New electronic structures providing localized MW field that can manipulate cellular processes with precision of hundred microns to tens of microns offer a unique tool to study the MW modulation up and close. Recognizing that the rotational frequency of water is in the range of MW frequency operating for successful inhibition, we here hypothesize a molecular mechanism for MW inhibition. We propose to test our hypothesis through two specific aims. First, we will validate the direct electrical response of neurons to MW through patch clamp and obtain insights into the cellular mechanism. Second, we will explore possible molecular mechanisms computationally and experimentally. Both direct MW irradiation and localized MW through a MW resonator device will be tested to assure the same mechanism applied and provide a foundation for future development of such devices for military applications, such as opium-free pain management in battlefield.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- May 05, 2022
- Source ID
- W911NF2210073
Entities
People
- Chen Yang
Organizations
- Army Contracting Command
- Boston University
- United States Army