Reactive Chemical Systems: Modulation of Reactivity through Responsive Supramolecular Assemblies for Triggering Chemical Amplification
Abstract
Activatable catalysis has been central to biological systems, as it forms the basis for precisely controlling many cellular processes. Artificial assemblies with such capabilities are primitive at best. Although the complexity with which nature assembles these processes is daunting, these systems do inspire the strategies by which we could tackle this challenge. Nature uses compartmentalization and responsive higher order molecular structures as the two key strategies for activatable catalysis. Inspired by these, we propose here a concerted set of approaches to develop artificial assemblies that offer the sophistication for catalysts to be turned off under one set of conditions, but activated under another. The proposed work will develop a fundamental understanding of the factors that underlie activatable chemical function using supramolecular assemblies. Developing such systems would have far-reaching broad impact in applications such as in sensing, diagnostics, controlled release, encrypted catalysts, environmental sustainability, nanoreactors, and self-healing.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Apr 19, 2023
- Source ID
- W911NF2310124
Entities
People
- Sankaran Thayumanavan
Organizations
- Army Contracting Command
- United States Army
- University of Massachusetts Amherst