Combatting Anti-Microbial Resistant Pathogens
Abstract
The Combatting Anti-Microbial Resistant Pathogens program is investigating fundamental methods for using preexisting host machinery as a technology to create medical countermeasures that degrade or deactivate pathogen targets. The DoD has long recognized the warfighter's outsized risk of exposure to biological threat agents and to infectious disease, including the increasing prevalence of antimicrobial-resistant (AMR) organisms that are ranked as a Tier 1 threat to the U.S. military. Similarly, the danger posed by bacterial biothreats persists with few countermeasures available. Key advances expected from this research include identifying methods to discover and develop new classes of therapeutics for AMR bacteria, bacterial biothreats, and other DoD-relevant diseases and threats. These approaches represent a significant departure from conventional therapeutics, which typically rely on a limited number of small molecules with a narrow set of targets and mechanism of action. Advances in this area may be applied to the mitigation of known, new, and emerging diseases that impact military readiness and pose a global health threat.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2024
- Source ID
- b2b7eac6e4693d56043729f9d0e5667d