Autonomous Diagnostics to Enable Prevention and Therapeutics (ADEPT)
Abstract
*Formerly part of Synthetic Biology The Autonomous Diagnostics to Enable Prevention and Therapeutics (ADEPT) program develops technologies to rapidly respond to a disease or threat, and improve individual readiness and total force health protection. This program utilizes synthetic genetic circuits to control cellular machinery and includes research to optimize orthogonality and modularity of genetic control elements, identify methods to increase sensitivity and specificity, and demonstrate methods to control cellular machinery in response to changes in physiological status. ADEPT enables the production of RNA-based vaccines, potentially eliminating the time and labor required for traditional manufacture of a vaccine while improving efficacy and safety. ADEPT also develops methodologies for measuring health-specific biomarkers from a collected biospecimen to enable diagnostics at the point-of-need (similar to home-use settings) or in resource-limited clinical facilities (i.e., point-of-care), in-garrison or deployed. The ADEPT program continues in FY 2012 in PE 0601117E, Project MED-01. Applied research for this program is funded in PE 0602115E, Project BT-01.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2013
- Source ID
- d88f138ca090bbed501a432083809688