In vivo Nanoplatforms (IVN)
Abstract
The In vivo Nanoplatforms (IVN) program developed the nanoscale systems necessary for in vivo sensing and physiologic monitoring and delivery vehicles for targeted biological therapeutics against chemical and biological (chem-bio) threat agents. The nanoscale components enabled continuous in vivo monitoring of physiological biomarkers. A reprogrammable therapeutic platform that targets gene regulatory sequences enabled tailored therapeutic delivery to specific areas of the body (e.g., cells, tissue, compartments) in response to traditional, emergent, and engineered threats. The key challenges to developing these systems included safety, toxicity, biocompatibility, sensitivity, response, and targeted delivery. The IVN program achieved diagnostic and therapeutic goals that enabled a versatile, rapidly adaptable system to provide operational support to the warfighter in any location.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2018
- Source ID
- d89bec76535fc5bf9467ddc047bfb163
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