Adaptive Immunomodulation-Based Therapeutics
Abstract
The Adaptive Immunomodulation-Based Therapeutics program developed platform technologies to interrogate and define the biological pathways to enhance operational readiness for DoD personnel. This program aided the warfighter by improving immune response, minimizing inflammation, and restoring critical organ function. One approach to achieve this capability required the development of new tools to stimulate and measure responses of the nervous system in order to harness the bioelectric code, enabling targeted therapy without the need for pharmacological products, ultimately reducing logistical requirements. An additional approach involved characterizing the host response in patients with severe infections, which provides a quantitative framework to guide therapy. Algorithms were developed to evaluate and predict various physiological conditions for military personnel. Advances made under the Adaptive Immunomodulation-Based Therapeutics program will offer new avenues for treating disease or organ function to improve force readiness.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2021
- Source ID
- e28e428c91767674fca36b8f722a3f20