Dialysis-Like Therapeutics (DLT)
Abstract
Sepsis, a bacterial infection of the blood stream, is a significant cause of injury and death among combat-injured soldiers. The goal of this program was to develop a portable device capable of controlling relevant components in the blood volume on clinically relevant time scales. Significant advances were made in sensing in complex biologic fluids, complex fluid manipulation, separation of components from these fluids, and mathematical descriptions capable of providing predictive control over the closed loop process. The developed device could save the lives of thousands of military patients each year by effectively treating sepsis and associated complications. Additionally, the device may be effective as a medical countermeasure against various chemical and biological (chem-bio) threat agents, such as viruses, bacteria, fungi, and toxins. Applied research under this program applied existing component technologies and integrated these products to create a complete blood purification system for use in the treatment of sepsis. Included in this effort was development, integration and demonstration of non-fouling, continuous sensors for complex biological fluids; implementation of high-flow microfluidic structures that do not require the use of anticoagulation; application of intrinsic separation technologies that do not require pathogen specific molecular labels or binding chemistries; and refinement of predictive modeling and control (mathematical formalism) with sufficient fidelity to enable agile adaptive closed-loop therapy.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2018
- Source ID
- e46e5208d193bb44afc324441077c4ee
Related Documents
- Root: BIOMEDICAL TECHNOLOGY