Restoring Cognitive Capability
Abstract
The Restoring Cognitive Capability program is developing novel drugs to provide rapid therapy for neuropsychiatric disorders experienced by warfighters and veterans. Active-duty military personnel face increased risk of acute and chronic neuropsychiatric dysfunction, limiting day-to-day function and return to duty. Current therapeutic approaches for many neuropsychiatric disorders (e.g., Post Traumatic Stress Disorder [PTSD], mood disorders, and substance abuse) rely on individual management with integrated psychiatric therapy and medication. However, most interventions approved for use in these conditions lack long-term efficacy, involve a logistical burden of treatment and/or carry a risk of serious adverse side effects. Novel drugs developed under this program will be designed to functionally interact with neuronal receptor subtypes known to play a role in these neuropsychiatric conditions, with the aim of enabling fast-acting and effective alleviation of neuropsychiatric dysfunction with single or minimal doses. Additional studies in this area seek to develop a mechanistic understanding of brain injury (UBI) resulting from blast, ultrasound, electromagnetic waves, or other directed-energy sources.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2024
- Source ID
- e665c773587759dba05ea754714f8cff