Dialysis-Like Therapeutics
Abstract
Sepsis, a bacterial infection of the blood stream, is a significant cause of injury and death among combat-injured soldiers. The goal of this program is to develop a portable device capable of controlling relevant components in the blood volume on clinically relevant time scales. Reaching this goal is expected to require significant advances in sensing in complex biologic fluids, complex fluid manipulation, separation of components from these fluids, and mathematical descriptions capable of providing predictive control over the closed loop process. The envisioned device would save the lives of thousands of military patients each year by effectively treating sepsis and associated complications. Initial basic research will develop the component technologies that will ultimately make up the integrated device. Included in this effort will be the development of non-fouling continuous sensors for complex biological fluids; design of high-flow microfluidic structures that do not require the use of anticoagulation; development of intrinsic separation technologies that do not require pathogen specific molecular labels or binding chemistries; and predictive modeling and control (mathematical formalism) with sufficient fidelity to enable agile adaptive closed-loop therapy. Applied research efforts are budgeted in PE 0602115E, Project BT-01.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2014
- Source ID
- e8be6f0c4df19f0b11da516d8d9a54de