Translational Understanding of Blast Effects (TransBlast)
Abstract
The TransBlast program is a prospective longitudinal study designed to rapidly advance understanding of blast-induced neurotrauma by closely coupling the biomechanical, medical, blast physics, and event measurement components into an integrated effort. The program will follow high-risk populations of service members to elucidate injury from both isolated and repeated events. Service members in the program are tested with a combination of imaging and neurocognitive functional exams prior to training, after training workup-but before deployment, and again after deployment. During training and deployed operations the service members wear blast dosimetry systems to document any exposures. All exposures are analyzed through detailed 3-dimensional reconstructions, combined with medical evaluations and testing records to determine the complex relationships between mechanical properties of blasts and the initiation of pathophysiologic responses. This effort builds on the successful deployment of the Blast Gauge measurement system in association with clinical indices of neurologic and psychiatric status to define a quantifiable relationship between timing and intensity of blast exposures and development and recovery of physiologic and clinic changes in an active duty population exposed to repetitive sub-clinical blast exposures and at an increased risk of involvement in clinically significant blast events.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2014
- Source ID
- ef11642261f596779cfc5181998c63f5
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- Root: BIOMEDICAL TECHNOLOGY