5) Discovery of Medical Countermeasures Against New and Emerging (DOMANE) - Enhanced Biodefense (ENBD)
Abstract
This effort focuses on predicting pathogenesis of pathogens and toxins while using artificial intelligence (AI) and machine learning (ML) to identify targets for both host and pathogen while conducting high throughput screens using new structural models with AI to predict and recommend potential therapeutics. It supports DOMANE thrusts like Pathogenesis and Toxicity forecasting using Multi-Organoid Systems (PATMOS) prototype, which develops an advanced- AI assisted multi-organoid system capable of forecasting pathogenesis of viral threats and toxicity of biotoxin threats. It supports other DOMANE thrusts like Medical Countermeasure Finder (MEDFIND) to prototype a flexible advanced AI-assisted system capable of harnessing repurposed drugs and generate effective therapeutic intervention strategies against viral and biotoxin threats.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2024
- Source ID
- f5211587f4c814c5f496186233249fa2