Systems Biology
Abstract
The core capability for multidisciplinary applied research in systems biology enables integration and analysis of complex data from human and animal studies and development of computational network models, allowing researchers to differentiate among molecular signatures (unique combinations of biological molecules corresponding to clinical conditions) of disease, and supports transition of research to clinical applications to diseases of military relevance. Applied research is being conducted to identify biological networks that are causative of illness in Post-Traumatic Stress Disorder (PTSD) and co-morbidities (presence of one or more diseases or disorders), coagulopathy (impaired ability to clot blood) of trauma, Traumatic Brain Injury, pain, suicide, infectious disease, and immune responses. In particular, the studies of PTSD are directed to refine biomarkers for screening, early diagnosis and therapeutic target discovery. Applied research is also aimed to identify (the substance itself and how it causes harm) toxic substances, e.g., toxic industrial chemicals. The molecular and physiological markers of intoxication are then applied to support diagnostic tools development of medical countermeasures. The task funding for the toxic substances research effort moves to Project 869 in FY17.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2018
- Source ID
- fbd151af633c9fec33cc16f3f02bd67a
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- Root: Medical Technology