Preventing Blood Stream Infections in Warfighters After Trauma
Abstract
Bloodstream infections (BSI) are a significant source of morbidity in service members that sustain combat-related injuries. Trauma temporarily degrades the efficacy of the host immune system thereby increasing the risk of life-threating opportunistic infections from fungi and bacteria that enter into the blood. If unchecked, bloodborne fungi and bacteria lead to debilitating conditions such as invasive fungal infections (IFI), sepsis, and shock. The Preventing Blood Stream Infections in Warfighters After Trauma program will develop a systems-level approach to prevent BSI in warfighters that suffer trauma from blast. Prophylactic systems circulating in the blood will be developed to bind infectious particles in the blood early and label pathogens for clearance and deliver drugs to destroy pathogens and/or restore healthy physiology. Ultimately this program will develop novel technologies that will protect service members from morbidity and mortality associated with BSI.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2025
- Source ID
- fc599588c0eca405069efabe339804df