Aptamer Selection and Integration in Nanoparticle-Based Detection Systems
Abstract
This project will discover novel biological recognition elements, specifically DNA and/or RNA oligomers known as aptamers that bind with high specificity and sensitivity to molecules of interest. Several different platforms are being investigated at the Air Force Research Laboratory in order to convert this binding event into optical and electrical signals which allow for implementation into a handheld sensor. The primary output of this program is to deliver a selection method for aptamers that can be used to detect multiple chemicals and detection assays for multiple analytes which have been examined with several platforms, as well as a prototype microfluidic field effect transistor sensor.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2012
- Source ID
- 568a35af2f9863b00a8e03b3409e70eb