STUDY OF THE INTERMEDIARY METABOLIC PATHWAYS OF 1,1-DIMETHYLHYDRAZINE (UDMH)
Abstract
The metabolic fate of 1,1-dimethylhydrazine (UDMH) was studied in female rats and dogs. The animals were given intraperitoneal injections of C14 labelled UDMH and, after an appropriate time, body tissues were examined by paper chromatography. Six compounds were found, although not ALL APPEARED IN EVERY TISSUE. Three major compounds were present in urine. Identification showed one (3-10%) to be the glucose hydrazone of UDMH, and another appeared to be unreacted UDMH (50-60%). The structure of the third major component (20-25%) was not determined, although its chemical and chromatographic behavior suggested that it was a hydrazone or hydrazide of a compound of higher molecular weight than acetic or pyruvic acid. Various analytical procedures were employed for the determination of UDMH in urine, and the trisodium pentacyanoaminoferroate (TPF) procedure was found to be the most sensitive and most specific qualitative method of those tested.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1962
- Accession Number
- AD0290509
Entities
People
- B.m. Vasta
- F.l. Aldrich
- Milton A. Mitz
Organizations
- Melpar