INFLUENCE OF TOTAL-BODY X-RAYS ON THE KINETICS OF ERYTHROCYTE ENZYMES AS A BIOLOGICAL DOSIM ETER AND BIOCHEMICAL STUDIES OF THE RAT BRAIN

Abstract

An internal X-ray dosimeter was found in a rat erythrocyte enzyme, nucleoside phosphorylase. At all total-body X-y doses tested from 100 to 1000 r, this enzyme was inhibited but the rate of inhibition was closely similar for the 250, 500, 750, and 1000 r in the postirradiation interval from 0 to 48 hours. However, the time and degree of recovery of enzyme activity postir radiation was dose dependent. A microtechnique was developed and initiated for testing the erythrocyte nucleoside phosphorylase activity which permits repeated sampling of blood from rats and other subjects. This allows the use of each animal as its own preirradiation control and the same animal may be used for multiple sampling of blood throughout the postirradiation period.

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Document Details

Document Type
Technical Report
Publication Date
May 31, 1963
Accession Number
AD0403354

Entities

People

  • Donald A. Rappoport

Organizations

  • University of Texas Medical Branch

Tags

DTIC Thesaurus Topics

  • Blood
  • Cells
  • Chemistry
  • Coenzymes
  • Dosimeters
  • Erythrocytes
  • Inhibition
  • Intervals
  • Metabolism
  • Mitochondria
  • Nucleosides
  • Nucleotides
  • Organophosphates
  • Pyridines
  • Radiation
  • Rodents
  • X Rays

Fields of Study

  • Biology
  • Physics

Readers

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  • Nuclear and Radiation Engineering.
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