DYNAMICS OF MORPHOLOGICAL CHANGES IN GUINEA PIG ORGANS AFTER INJECTION OF PENICILLIN

Abstract

A single parenteral injection of 30 guinea pigs with penicillin produced within 24 hours widespread lesions of the blood vessels in the form of vasculitis combined with focal myocarditis, focal encephalitis, bronchospasm, and liver necroses. These changes resemble the morphological picture of an allergic process. The changes in the severe cases resulted in the death of the animals. The changes were reversed when the course was mild. Localization of the changes in the intestines led to the subsequent development of gram-negative flora.

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Document Details

Document Type
Technical Report
Publication Date
Oct 23, 1967
Accession Number
AD0675632

Entities

People

  • E. Y. Severova

Organizations

  • United States Army Biological Warfare Laboratories

Tags

Communities of Interest

  • Ground and Sea Platforms

DTIC Thesaurus Topics

  • Animals
  • Anti-Bacterial Agents
  • Blood
  • Blood Vessels
  • Cardiovascular Diseases
  • Cardiovascular System
  • Cells
  • Gastrointestinal Tract
  • Heart
  • Hemorrhage
  • Intestines
  • Large Intestine
  • Microvessels
  • Muscle Fibers
  • Rodents
  • Tissues
  • Vascular Diseases

Fields of Study

  • Biology
  • Medicine

Readers

  • Microbial Pathology
  • Neuroscience
  • Toxicology/Environmental Toxicology