THE CYTOCHEMISTRY OF ANOXIC AND ANOXIC-ISCHEMIC ENCEPHALOPATHY IN RATS. II. ALTERATIONS IN NEURONAL MITOCHONDRIA IDENTIFIED BY DIPHOSPHOPYRIDINE AND TRIPHOSPHOPYRIDINE NUCLEOTIDE DIAPHORASES

Abstract

Alterations in neuronal mitochondria have been described in the course of postmortem autolysis and in both anoxic and anoxic-ischemic encephalopathy. The mitochondria were identified in formol-calcium fixed tissue by virtue of their diphosphopyridine and triphosphopyridine nucleotide diaphorase activity. Swelling of the mitochondria was noted during the early phases of both autolysis and necrobiosis. Loss of enzyme activity became prominent during the later phases. In some cases the earliest cytochemical lesions preceded those which could be detected by Nissl stains and by hematoxylin and eosin.

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Document Details

Document Type
Technical Report
Publication Date
Dec 19, 1960
Accession Number
AD0675652

Entities

People

  • Norwin H. Becker

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DTIC Thesaurus Topics

  • Arteries
  • Blood Vessels
  • Brain
  • Cell Physiological Processes
  • Cells
  • Central Nervous System
  • Cerebral Cortex
  • Cerebral Hypoxia
  • Chemistry
  • Lysosomes
  • Medical Personnel
  • Mitochondria
  • Navy
  • Nervous System
  • Neuroglia
  • Spinal Cord

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  • Biology
  • Chemistry

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