The Acute Hyperbaric Toxicity of Carbon Monoxide
Abstract
The effects of elevated pressures (25, 50, 75, and 100 psig) on the toxicity of carbon monoxide (CO) in guinea pigs, rats and mice were examined in a series of 4-hr exposures. The partial pressure of oxygen (pO2) was maintained between 140 and 160 mm Hg during all exposures. The LC50 values (lethal concentration of carbon monoxide for 50% of the animals exposed) expressed in milligrams per cubic meter of CO, were not appreciably altered by increases in pressure within the range studied. At death, the blood carboxyhemoglobin concentrations showed very little variation regardless of the exposure pressure.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 26, 1970
- Accession Number
- AD0717785
Entities
People
- C. S. Rose
- Jason B. Siegel
- L. J. Jenkins Jr.
- R. A. Jones