METABOLISM AND PHARMACOLOGY OF FLUORINE-CONTAINING COMPOUNDS
Abstract
Acute inhalation, intraperitoneal and/or oral toxicities of AMOX and TAMA were determined in rats and mice. IP absorption was studied in rats. AMOX produced strong irritation resulting in pulmonary edema and hemorrhage after inhalation; and local denatured changes and accumulation of clear exudate after intraperitoneal injection. TAMA was less toxic on the weight basis. Both AMOX and TAMA were quickly absorbed after IP injection. Fluoride increased quickly in the blood and concentrated in various tissues especially in the thyroid, bone and teeth. Most of the administered fluoride was excreted in the urine and a considerable amount was also recovered in the feces.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1966
- Accession Number
- AD0801537
Entities
People
- Cheng-chun Lee
Organizations
- MRIGlobal