CONCERNING THE PATHOGENESIS OF THE TULAREMIA INFECTION IN NONIMMUNE AND IMMUNE ORGANISMS
Abstract
The infectious process in the organism of a tularemia immune guinea pig, following its infection with a virulent strain, proceeded mainly benignly and was characterized by a sharp limiting of the multiplication of the causative agent in the organs. In contrast to nonimmune pigs, the granulomatous process in immune pigs bore the features mainly of productive inflammation and the granulomas which appeared in them were not subjected to necrotization. The main difference in the process in nonimmune and immune guinea pigs was that in the organism of nonimmune animals the phase of hematogenic dissemination and focal distribution of the infection passed into the phase of septicemia and in the organism of immune pigs the phase of hematogenic dissemination and focal distribution passed to the phase of extinction of the infection.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1966
- Accession Number
- AD0815554
Entities
People
- A. P. Gindin
- R. A. Savelyeva
Organizations
- United States Army Biological Warfare Laboratories