INVESTIGATIONS INTO A SIMPLIFIED MODIFICATION OF THE IMMUNEFLUORESCENCE TEST FOR TREPONEMES (IFTT)

Abstract

The results of the studies, made with a simplified modification and the original method of IFTT, showed complete agreement in 44 syphilitic patients. In the remaining patients, examined as controls after treatment, the test made by its simplified modification gave positive result, while the original form of the test gave doubtful results. In twenty-five patients who had a markedly positive qualitative reaction, quantitative examinations were made with both the simplified modification and the original method. In all cases, the titres agreed within the range of one dilution. In the control group of 12 non- syphilitic persons, a weak non-specific fluorescence was found in four cases, which, according to the accepted principles, was marked plus-minus, or one-plus. In the remaining 121 cases, the result was completely negative. The results indicate that the simplified modification of the IFTT is distinguished by a very great sensitiveness, and its specificity seems to be good enough for the purposes of mass examinations.

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Document Details

Document Type
Technical Report
Publication Date
Sep 14, 1966
Accession Number
AD0835185

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  • Wanda Lesinska-manikowska

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  • United States Army Biological Warfare Laboratories

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