Evaluation of RSDL, M291 SDK, 0.5% Bleach, 1% Soapy Water and SERPACWA. Part 12: Challenge with EA1212 (GF, cyclosarin)

Abstract

An important objective of the Project Solicitation for Agent Therapeutics (Task Area 2.H) was to determine the effectiveness of current medical countermeasures against the acute toxicity of nerve agents. This project evaluated the efficacy of skin decontamination products and barrier skin creams. Doctrine described the use of Skin Exposure Reduction Paste Against Chemical Warfare Agents (SERPACWA)as a barrier skin cream and the M291 Skin Decontamination Kit (SDK), 0.5% hypochlorite solution (household bleach diluted 1 to 10)and1% soapy water solution (liquid dish detergent) to decontaminate intact skin exposed to chemical warfare agents. Reactive Skin Decontamination Lotion (RSDL) was approved by the FDA in 2003 and subsequently selected as the Joint Services Personnel Skin Decontamination System (JSPDS) to replace the M291 SDK. This report, the twelfth in a series, directly compares the efficacy of the barrier skin cream SERPACWA and the four listed decontamination products in the haired guinea pig model following exposure to GF(EA1212).

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2016
Accession Number
AD1012119

Entities

People

  • Bryce F. Doxzon
  • Ernest Jr H. Braue
  • Horace L. Lumpkin
  • Jennifer L. Devorak
  • Kelly H. Smith
  • Robert S. Stevenson

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

DTIC Thesaurus Topics

  • Animals
  • Chemical Warfare
  • Chemical Warfare Agents
  • Data Analysis
  • Databases
  • Decontamination Kits
  • Factor Analysis
  • Health Services
  • Information Science
  • Medical Countermeasures
  • Medical Personnel
  • Nerve Agents
  • Rodents
  • Statistical Analysis
  • Therapy
  • Toxicity
  • Warfare

Readers

  • Critical Infrastructure Protection in CBRN and WMD Threats.
  • Geochemistry
  • Toxicology/Environmental Toxicology